Evaluation of serum adenosine deaminase levels with components of metabolic syndrome

Abstract

Introduction: Metabolic syndrome is a major worldwide health problem leading to markedly increased mortality and serious morbidity. The major features of the metabolic syndrome include central obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, hyperglycemia, and hypertension. Adenosine, regulates adipokines secretion by adipose tissue. They will regulate free fatty acid oxidation and it has the capacity to act like insulin on adipose tissue. Increased Adenosine Deaminase(ADA) activity leads to decrease in adenosine in adipose tissue. Since a relationship exists between adenosine deaminase and metabolic syndrome, we have undertaken a preliminary study to determine its plasma activity in metabolic syndrome cases and highlight its importance by comparing its activity with each component of metabolic syndrome. Objectives: To estimate serum ADA, Fasting blood sugar (FBS), Triglyceride (TG), HDL, Waist circumference (WC) & Blood pressure (BP) in cases and controls and to correlate serum ADA with FBS, TG, HDL, WC & BP in cases of Metabolic syndrome. Materials & Methods: The study was conducted on 50 diagnosed cases of Metabolic syndrome and 50 age and sex matched healthy subjects. ADA estimated by Guisti and Gulanti method, FBS by GOD - POD method, HDL-C by Immunoinhibition method, TG by GPO-PAP method, Waist circumference & BP measured as per WHO criteria. Statistical analysis was done using SPSS-17. Results: Serum ADA, FBS & TG levels, waist circumference, Blood Pressure levels were significantly elevated in cases compared to controls. Serum HDL levels was significantly decreased in cases compared to controls. Correlation was positive and significant when ADA activity was compared with FBS, TG, WC & BP and correlation was negative and significant when ADA activity was compared with HDL in cases. Conclusion: These findings clearly project an early detection of elevation of ADA levels may help in early prevention and management o