Evaluation of Resection Margin by Intraoperative Frozen Section Biopsy in Breast Conservative Surgery for Early Breast Carcinoma

Abstract

Background: Breast cancer is currently the second leading cause of cancer deaths in women. Early detection and accurate classification of suspicious masses as benign or malignant is important for arriving at an appropriate treatment plan. Aims: To evaluate the resection margin by intra-operative frozen section in breast conserving surgery for early breast carcinoma. Methods: This cross sectional study was carried out in the department of general surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. A total of 20 patients with early stage breast carcinoma underwent surgery were included in this study. Admitted patients with diagnosis of invasive ductal carcinoma of the breast, patient who gave consent for research purpose, patients diagnosed with stage I & II breast cancer, small (up to 4 cm) unifocal tumor and clinically negative axillary nodes were enrolled in this study. Statistical analyses of the results were obtained by using window based computer software devised with Statistical Packages for Social Sciences (SPSS-22). Results: It was observed that more than one third (40.0%) patients belonged to age 41-50 years. The mean age was 45.55±10.94 years with ranged from 28 to 75 years. Half (50.0%) patient’s educational level was primary. Majority (85.0%) patient’s occupational statuses were housewife. Majority (90.0%) patients had lump size >2-≤5 cm. The mean lump size was 2.89±0.66 cm with ranged from 1.5 to 4 cm. Three fourth (75.0%) patients had lump in the right breast. Almost two third (60.0%) patients had lump in the upper outer quadrant of breast. Two (10.0%) patients had Grade I and 18(90.0%) had Grade II tumor. Three fourth (75.0%) patients had resected tumor of T2 >2-≤5 cm size. The mean size of resected toumour was 2.65±0.62 cm with ranged from 1.4 to 3.8 cm. The frequency of positive resection margin on frozen section was 3 (15%). Among them 1 (33.3%) patient had positive superior margin and 2 (66.7%) had positive lateral ....