Abstract
ABSTRACT Introduction and objective: This study was carried out to analyze the relationship between hematocrit and lipid profile in adults. Material and method: A sample composed of complete blood counts and lipid profiles from the database of Hospital das Clinicas da Universidade de Sao Paulo (HCUSP), Sao Paulo, Brazil, was used in the analysis. Hematocrit was organized in five groups that were compared with total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), non-high-density-lipoprotein cholesterol (NHDL-C) and high-density-lipoprotein cholesterol (HDL-C) by means of chi-squared and Kruskal-Wallis tests. Results: Both tests showed a relevant correlation between hematocrit and lipid profile, considering a p-value < 0.05. Moreover, descriptive statistics revealed that the higher the hematocrit, the higher the proportion of people without recommended levels of each type of cholesterol, such TC, LDL-C, and NHDL-C. Just HDL-C showed an inverse association compared to the other variables, with an increased proportion of recommended levels along with rising of hematocrit. Conclusion: The relationship between hematocrit and lipid profile in all aspects of this study was more evident in women; nevertheless, the higher proportion of not recommended levels of HDL-C was shown in men. The reverse cholesterol transport probably plays an important role in the increase of cholesterol levels in blood in the presence of high hematocrit, by interaction of HDL-C and erythrocytes. Thus, further studies are necessary to elucidate these findings and to describe more aspects of the reverse cholesterol transport and its relationship with hematocrit and lipid profile.
Highlights
Introduction and objectiveThis study was carried out to analyze the relationship between hematocrit and lipid profile in adults
Hematocrit was organized in five groups that were compared with total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), non-high-density-lipoprotein cholesterol (NHDL-C) and high-density-lipoprotein cholesterol (HDL-C) by means of chi-squared and Kruskal-Wallis tests
Considering that the increase of hematocrit can be related to a cascade of hemodynamic and metabolic alterations that contribute to higher cardiovascular risk, this study aims at assessing the correlation between hematocrit and variations of TC, its fractions and associated lipoproteins in a population of individuals treated at a tertiary care hospital
Summary
Introduction and objectiveThis study was carried out to analyze the relationship between hematocrit and lipid profile in adults. Conclusion: The relationship between hematocrit and lipid profile in all aspects of this study was more evident in women; the higher proportion of not recommended levels of HDL-C was shown in men. Blood is a complex fluid, responsible for delivering nutrients to most body tissues and for collecting metabolic wastes, avoiding tissue accumulation and toxicity It is composed of an extracellular fluid rich in proteins – plasma – and cells, such as erythrocytes, leukocytes and platelets[1]. Erythrocytes do not leave the circulatory system: they always remain within blood vessels[2], actively participating in homeostasis maintenance Their primary function is the transport of gases bound to hemoglobin, it is evident that erythrocytes have other interactions, such as the capacity of diffusional exchange of cholesterol, but with low capacity for cholesterol storage[3]. This function makes us suppose there is a possible correlation between circulating erythrocytes and transport of cholesterol and its fractions
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