Abstract
The study of irradiation of brain cells with exposure to accelerated charged particles is essential topic in modern radiobiological research. Using Geant4-DNA based Monte-Carlo simulation of particle tracks we studied initial energy deposition and radiolytic species production within critical targets on neural cells: voltage-gated membrane channels and synaptic receptors. According to the modeling results the most probable targets for radiation damage can be attributed to synaptic receptors of GABA and NMDA type rather than ion channels. Indirect damage caused by chemical interaction with free radicals dominates over direct ionization events. We also provide an estimation for damage induction efficiency after the exposure with particles of different dose and linear energy transfer.
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