Abstract
Considering how much protein is loaded into the process, the crosslinking solution concentration and the weight percentage of the alginate/hydroxyethyl cellulose coating material, this study presented the details of optimization of the microencapsulation process. Optimization was done with an objective of maximizing the encapsulation efficiency of the microparticle fabricated using external ionotropic gelation method. Results showed that the process is capable of achieving around 75% encapsulation efficiency when protein loading is around 15 wt%, alginate/hydroxyethyl cellulos is about 2 wt% and the CaCl2 solution should be 3 wt%. This was done using Box-Behnken methodology wherein the predicted model was found to have good predictive capability. Analysis also showed that the process is affected by how much protein drug is loaded into the system and the interactions between crosslinking solution concentration with bovine serum albumin (BSA) loading as well as the strong relationship between alginate/hydroxyethyl cellulos concentration with itself.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
