Abstract
Sauauria vulcani serves as a rich source of secondary metabolites, including triterpenoids, steroids, tannins, and flavonoids. The present study aimed to assess the biological activities of the S. vulcani leaves, which is an indigenous plant found in West Indonesia. Dried S. vulcani leaves were macerated with hexane to obtain HPE, ethyl acetate to obtain EPE, and methanol to obtain MPE. The TPC was assessed using the Folin-Ciocalteu method, and the TFC was determined utilizing the aluminum chloride assay. Antioxidant activity was evaluated through the DPPH and ABTS assays. The α-amylase inhibition activity of HPE, EPE, and MPE was assessed using the DNS method. The study identified various secondary metabolites in the extracts, including phenolics, flavonoids, triterpenoids, steroids, tannins, and saponins. MPE exhibited the highest TPC and TFC with values of 38.501 ± 0.891 mg GAE/g and 31.436 ± 0.797 mg QAE/g, respectively. In the DPPH and ABTS assays, MPE showed the highest antioxidant capacity, with IC50 values of 54.74 µg/mL and 61.10 µg/mL, respectively. EPE and MPE of S. vulcani displayed increased levels of polyphenolic content, which contributed to their antioxidant effects. The α-amylase inhibitory studies showed that the extracts of S. vulcani (EPE, MPE) had significant inhibitory effects. This study suggests that the EPE and MPE extracts of S. vulcani have the potential as natural sources of bioactives for drug development.
Published Version
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