Evaluation of Physicochemical Parameters of Piroxicam 20 mg Tablets Commercially Available in District Larkana, Sindh

Abdullah Dayo,Arslan Ahmer,Bilawal Shaikh,Komal Zaman Khan,Maryam Qazi,Mudassar Iqbal Arain,Muhammad Ali Ghoto,Rao Irfan,Ubed-Ur-Rehman Mughal,Waqar Ahmed

doi:10.9734/jpri/2020/v32i3230936

Abstract

The objective of this study is to evaluate the physicochemical parameters of Piroxicam 20 mg Tablet brands. A comparative qualitative research study was conducted for a period of six months. A total of five different brands of active Piroxicam tablets were selected. All samples were purchased from various local markets of Larkana Sindh. These collected samples were coded as PIX01, PIX02, PIX03, PIX04 and PIX05 for minimalism. Specific physicochemical quality control lab tests included Aesthetic test, Diameter and Thickness test, Weight variation, Mechanical strength and Friability test were performed on each sample according to standards and results were compared. Packing of all samples was observed according to GMP guidelines. Data was analyzed by using statistical software SPSS 24.00. Most of the brands were within official limits of United State Pharmacopeia (USP) except brand PIX05 showing variation in hardness test, whereas two brands PIX03 and PIX05 fail in friability test as well as powder material seen inside of blisters in aesthetic test. Dissolution test for each brand of Piroxicam was performed in which PIX02, 04 and 05 failed. It was concluded that from this study after in vitro physical evaluation of various brands of Piroxicam tablets, most of the brands are being manufactured under compliance of GMP guidelines as well as specifications described under USP. Traces of powder material inside of blister in aesthetic test and unsatisfactory result in friability and hardness test in same brand indicating the deviation of GMP guidelines and USP specification which may cause the out of specification result in chemical test.

Highlights

Pain is worrying sensation, which is caused by forceful diminishing of spurs or inducement, another specific definition for the pain which is being described by the international association for the study of pain [1], A hostile corporeal and sensitive familiarities associated with actual and potential damage of such type of tissues or may be defined as diminishing of such type of tissues, where as in medical science It has various outline for its definition or description [2]
Whenever we are discussing the pain management everybody want to get rid of from unpleasant sensation and everybody want to recover the damaged tissue and avoiding to have same exposure in future some time pain is recovered by removing the harmful stimuli and body is recovered whereas some time pain appears within body without identifying any noxious stimulus or without any damaging of tissues – pain is only reason for the consultation of physician in many developing counties [4], as whenever patients feels unpleasant sensation it alter the normal physiology of the patient and medically patients want to recover from distressing feelings
Total 05 different brands of Piroxicam were taken in order to perform physicochemical tests city and each brand was labeled with the names of PIX01, PIX02, PIX03, PIX04 and PIX05

Summary

Introduction

Pain is worrying sensation, which is caused by forceful diminishing of spurs or inducement, another specific definition for the pain which is being described by the international association for the study of pain [1], A hostile corporeal and sensitive familiarities associated with actual and potential damage of such type of tissues or may be defined as diminishing of such type of tissues, where as in medical science It has various outline for its definition or description [2]. Simple pain killer medicines are used up to 70% besides this various factor are involved to reduce the intensity of pain [5]. Such as factors associated with psychology of the person [4] e.g:- Social support excitement, hypnotic recommendation these factors are used frequently along with medicine to reduce the pain and unwanted sensation either acute or chronic [5]. In rare case it is observed that physician suggest for euthanasia when all others reasons for pain management become fruitless. When person is suffering from severe illness with rich intensity of pain than he may trying to withdraw from his life and more for euthanasia [6]

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Conclusion