Evaluation of Phenotypic Markers of Hyperandrogenism in Patients with Preeclampsia With Severe Features [10B

Abstract

INTRODUCTION: Studies have shown an association between polycystic ovarian syndrome (PCOS), a hyperandrogenic condition, and increased risk of pre-eclampsia (PEC). Certain phenotypes, such as the ratio of the length of the second and fourth digits of the hand (2D:4D) have been suggested markers of elevated prenatal androgen exposure. This study seeks to evaluate the relationship between 2D:4D ratio, earlobe crease, feet type, and risk of developing PEC with severe features (PEC-S). METHODS: This is a case control study including women in the immediate post-partum period. Patients with diagnosis of PEC-S were examined in the postpartum unit, and the following were recorded: measured length of the 2D and 4D of the right hand, presence/absence of an earlobe crease, and feet type. Descriptive statistical analysis was used. RESULTS: 150 participants were included in the study (51 cases and 99 controls). The mean 2D:4D ratio was similar in both groups 0.96 (p=0.552). There was a marginally significant relationship between presence of earlobe crease and PEC-S, with 19.6% cases having an earlobe crease compared to only 9.1% of controls (p=0.075). Concerning feet type, cases had 68.6% Egyptian, 32.5% Greek, and 7.8% Roman compared to controls 54.5%, 39.4%, 6.1% respectively (p=0.149). CONCLUSION: There is no significant association between the 2D:4D ratio or feet type and PEC-S. Thus, we concluded that these are not valid phenotypic markers for early identification of preeclampsia. There was a marginal association between presence of earlobe crease and PEC-S. We recommend this, and other phenotypes of hyperandrogenism be investigated further.