Abstract
The aim of this study was to explore the use of Pharmasolve® as a new kind of permeability enhancer in ophthalmic drug delivery systems. The ocular irritation of different concentrations of Pharmasolve® on rabbit eyes was evaluated in detail. Four drugs ranging from hydrophilic to lipophilic, namely ribavirin, puerarin, enoxacin, and ibuprofen, were used as model compounds to investigate the effects of different concentrations of Pharmasolve® on the corneal permeability. The mechanism of ocular permeation enhancement of drugs by Pharmasolve® was also discussed. The results showed that Pharmasolve® presented no irritation when the concentration used was lower than 10%. Pharmasolve® could enhance the ocular permeability of the four test drugs; the maximum enhancement in Papp was 4.04, 2.76, and 2.67-fold for ribavirin, enoxacin, and puerarin, respectively; 2.5% (v/v) Pharmasovle® increased the Papp by about 1.47-fold for ibuprofen; which suggested that it would have a great potential to be used as a safe and effective penetration enhancer in ocular drug delivery systems in the future.
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