Abstract
The family Pasteurellaceae Pohl contains gramnegative, facultatively anaerobic and fermentative bacteria of the genera Pasteurella, Haemophilus, and Actinobacillus. Of these genera, Haemophilus somnus, Pasteurella multocida and Pasteurella haemolytica are prominent pathogens in domestic cattle causing severe diseases and major economic losses. Mechanisms of immunity to these bacteria have been difficult to determine, and efficacious vaccines have been a challenge to develop and evaluate.
 In this review, we will summarize current published data on antigens and immunity associated with H. somnus, P. multocida, and P. haemolytica. This will be followed by a discussion of experimental studies conducted in our laboratories using commercial P. haemolytica vaccines.
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