Abstract
It is important to determine the functional changes of organs that occur as a result of aging, the understanding of which may lead to the maintenance of a healthy life. Glucose metabolism in healthy bodies is one of the potential markers used to evaluate the changes of organ function. Thus, information about normal organ glucose metabolism may help to understand the functional changes of organs. [18F]-Fluoro-2-deoxy-2-d-glucose (18F-FDG), a glucose analog, has been used to measure glucose metabolism in various fields, such as basic medical research and drug discovery. However, glucose metabolism changes in aged animals have not yet been fully clarified. The aim of this study is to evaluate changes in glucose metabolism in organs and brain regions by measuring 18F-FDG accumulation and 18F-FDG autoradiography with insulin loading in aged and young wild-type mice. In the untreated groups, the levels of 18F-FDG accumulation in the blood, plasma, muscle, lungs, spleen, pancreas, testes, stomach, small intestine, kidneys, liver, brain, and brain regions, namely, the cortex, striatum, thalamus, and hippocampus, were all significantly higher in the aged mice. The treated group showed lower 18F-FDG accumulation levels in the pancreas and kidneys, as well as in the cortex, striatum, thalamus, and hippocampus in the aged mice than the untreated groups, whereas higher 18F-FDG accumulation levels were observed in those in the young mice. These results demonstrate that insulin loading decreases effect on 18F-FDG accumulation levels in some organs of the aged mice. Therefore, aging can increase insulin resistance and lead to systemic glucose metabolism dysfunction.
Highlights
Muscle Heart Lung Spleen Pancreas White adipose tissue Testis Stomach Small intestine Large intestine Kidney Liver Brown adipose tissue Brain is important in implementing age-appropriate preventive and therapeutic strategies
It is widely accepted that aging is accompanied by an increase in insulin r esistance[7,8]. This age-related insulin resistance has been variously attributed to several factors, including mitochondrial dysfunctions, reduced lean muscle mass and elevated adiposity, hormonal changes, increased oxidative stress, inflammation, and reduced physical a ctivity[9,10,11,12,13,14]
18F-FDG accumulation has been investigated in various fields, such as basic medical research and drug discovery, changes in glucose metabolism evaluated using 18F-FDG in aged animals have not yet been fully clarified
Summary
Muscle Heart Lung Spleen Pancreas White adipose tissue (superior pole of epididymis) Testis Stomach Small intestine Large intestine Kidney Liver Brown adipose tissue (between the shoulder blades) Brain is important in implementing age-appropriate preventive and therapeutic strategies. It is widely accepted that aging is accompanied by an increase in insulin r esistance[7,8] This age-related insulin resistance has been variously attributed to several factors, including mitochondrial dysfunctions, reduced lean muscle mass and elevated adiposity, hormonal changes, increased oxidative stress, inflammation, and reduced physical a ctivity[9,10,11,12,13,14]. These studies do not provide insights into organ-specific differences in insulin resistance. In this study, we attempted to clarify the changes in glucose metabolism that occur with aging by comparing 18F-FDG accumulation levels after insulin loading in aged and young wild-type mice
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