Abstract
By scanning biological tissues in vivo and in vitro with optical coherence tomography, it is found that liquid paraffin can enhance the percutaneous penetration of glycerol in deep layers of tissue and take synergistically optical clearing effect with glycerol. It is shown from experimental results that 30% - 50% liquid paraffin glycerol solutions have the best enhancement effect. Considering the refractive index of liquid paraffin and its medicinal value, we think liquid paraffin will play an important role in optical clearing as the penetration enhancer of glycerol in future clinical research.
Highlights
Optical imaging technologies, utilizing the inherent optical properties of biological tissues, such as light scattering, absorption, polarization, and fluorescence, have many advantages over X-ray computed tomography (X-CT), magnetic resonance imaging (MRI) and ultrasound imaging in the aspects of safety, cost, contrast and resolution
The dominant reason of limiting the imaging depth and contrast in optical imaging within therapeutic and diagnostic optical window is multiple scattering in biological tissues, which is mostly contributed by refractive index mismatch [2]
The hairdepilated skin of rat is firstly scanned to observe the variation of imaging contrast and the penetration depth of the combined liquid paraffin with glycerol mixed solutions
Summary
Optical imaging technologies, utilizing the inherent optical properties of biological tissues, such as light scattering, absorption, polarization, and fluorescence, have many advantages over X-ray computed tomography (X-CT), magnetic resonance imaging (MRI) and ultrasound imaging in the aspects of safety, cost, contrast and resolution. Multiple scattering and absorption attenuate the effective light intensity that reaches internal tissue, diminish the detecting depth, image contrast and image definition They limit the clinical application of some optical imaging techniques. It is considered that optical clearing technique can effectively reduce the multiple scattering of light and improve the effect of optical diagnostics of tissue [2,6]. Some penetration enhancers can be added in OCAs to improve the delivery of agents in skin so as to achieve a better optical clearing effect. Considering the important value of OCAs, we expect to find safe and more effective agents from raw materials of clinical medicaments and cosmetics Their optical clearing effects can be evaluated with optical coherence tomography (OCT) as Refs. The enhancement results of OCT images of rat skin in vitro and human skin in vivo by applying liquid paraffin glycerol solution are shown and some possible explanations are given in this paper
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