Evaluation of Oocyte Quality in Polycystic ovarian syndrome (PCOS) Women Undergoing Controlled Ovarian Stimulation with Antagonist Protocol Followed by Frozen Embryo Transfer

Abstract

Published on: October 2022Journal of Young Pharmacists, 2022; 14(4):412-415Original Article | doi:10.5530/jyp.2022.14.83 Authors:Oviya Chitharthan*, Mahalakshmi Saravanan, Sarguna Devi, Priya SenthilDepartment of Reproductive Medicine, ARC International Fertility and Research Centre, Egmore, Chennai, Tamil Nadu, INDIA. Abstract:Background: Polycystic ovarian syndrome (PCOS) is a highly prevalent hormonal disorder noted among 5-8 percent of women in the age group of 15-40 years. Genetics, diet and lifestyle play a crucial role in modulating PCOS by managing a healthy weight and abdominal circumference. In treatment procedure GnRH antagonist protocol was used as a preferred mode of stimulation to reduce the side effects of GnRH agonist procedure. The objective of this study is to evaluate the oocyte quality under controlled ovarian stimulation along with antagonist regimen, ensued by the transfer of frozen embryos. Materials and Methods: This research is retrospective and analytical. The data was analysed utilizing 100 PCOS and 100 non-PCOS subjects. From the retrieved data, base line characteristics, quality of oocyte, M2 conversion rate, blastocyst formation rate, clinical viable pregnancy rate was noted. Antagonist protocol followed by frozen embryo transfer was assessed between PCOS and Non-PCOS women. Results: The M2 conversion rate was significantly higher in the Non-PCOS group while the need for double antag was significantly more in the PCOS group. No variation was observed in the rate of fertilization, cleavage rate, blastocyst conversion rate and frozen embryo rate between PCOS and non-PCOS group. Conclusion: Antagonist protocol would be a better protocol option for PCOS women helping in reducing the risk of OHSS without compromising on quality of embryo, fertilization rate and clinical pregnancy rate.Keywords: PCOS, Infertility, OHSS, Antagonist protocol, Oocyte Quaity, Frozen embryo Transfer.