Abstract
ABSTRACT Aims To assess efficacy and safety of omeprazole in laryngitis due to laryngopharyngeal reflux disease (LPRD). Materials and methods It was a prospective, randomized, open label study conducted in 90 patients with laryngitis due to LPRD. Group A (n = 45) received omeprazole and advice about life style modification, group B (n = 45) received only advice about life style modification. Reflux symptom index (RSI), reflux finding score (RFS), quality of life (QoL) and voice handicap index (VHI) were evaluated at 0, 4 and 8 weeks. Results P ercentage r eduction i n R SI a nd R FS w as s ignificantly higher in group A after 8 weeks (37 vs 29%, 18 vs 13% respectively). Excess throat mucus, clearing of throat and erythema of posterior larynx improved considerably in group A compared to group B. Conclusion Omeprazole could be a significant addition to life style modification in LPRD patients particularly for signs and symptoms, such as excess throat mucus, clearing of throat and erythema of posterior larynx. How to cite this article Doshi K, Varghese A, Badyal DK. Evaluation of Omeprazole in the Treatment of Laryngopharyngeal Reflux Disease: A Single Center, Prospective and Randomized Study. Int J Otorhinolaryngol Clin 2015;7(2):45-50.
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