Research on the curative effects of modified wendan decoction combined with omeprazole on laryngopharyngeal reflux disease

Abstract

Objective To study the effects of modified wendan decoction combined with omeprazole on laryngopharyngeal reflux disease (LPRD). Methods From December 2011 to July 2016, 180 patients with LPRD in the First People’s Hospital of Jinzhong were randomly divided into study group and control group, with 90 cases in each group. The patients in control group orally took omeprazole (20 mg each time, 2 times per day)and domperidone(10 mg each time, 3 times per day), and the patients in study group took omeprazole as the same as above, and took modified wendan decoction in addition, decocted in water, took twice daily in the morning and evening. Patients kept continuous medication for 8 weeks to observe the clinical efficacy. After treatment, the total effective cases were counted and followed up. The reflux symptom index (RSI) symptom scores and reflux finding score (RFS) scales were evaluated in the 4th, 8th and 12th month respectively to record the recurrence. Results In the study group, treatments were apparently effective in 47 cases, effective in 39 cases, invalid in 4 cases, and the total effective rate was 95.56%. In the control group, apparently effective in 35 cases, effective in 38 cases, invalid in 17 cases, and the total effective rate was 81.11%. The effect in the study group was better than that in the control group (P<0.01). After one-year follow-up, 24 cases of the 86 patients in the study group recurred, while 27 cases of the 61 patients in the control group recurred. The recurrence rate in the study group was lower than that in the control group(P<0.05). Conclusions The effects of modified wendan decoction combined with omeprazole in the treatment for laryngopharyngeal reflux disease are much better than that of simply oral western medicine. It can significantly reduce the forward recurrence rate. Key words: Laryngopharyngeal reflux disease; Modified wendan decoction; Reflux symptom index; Reflux finding score