Abstract
DNA polymerase beta (Pol β) is an essential enzyme that plays a critical role in the repair of the DNA base damage and single stranded breaks (SSBs) commonly produced by ionizing radiation (IR). If left unrepaired clusters of such lesions can result in double strand breaks (DSBs), the major cause of cell death due to IR. Inhibitors of poly ADP ribose polymerases (PARP) another key family of proteins involved in the repair of SSBs have become important drugs in treatment of many cancers when combined with DNA damaging agents such as radiation or alkylating agents.
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