Abstract
The purpose of this study was to investigate the disintegrating properties of native arrowroot starch and pregelatinized arrowroot starch in comparison with corn starch and sodium starch glycolate (Explotab®). Tablets were prepared by direct compression. The tablet formulations contained dibasic calcium phosphate as filler and magnesium stearate as lubricant. Each starch at various concentrations between 2-10 % w/w was used in formulation as disintegrant. The swelling volume and weight of starches and disintegration time of tablets were evaluated. At 2% w/w concentration of starch, the pregelatinizaed starch provided disintegration time faster than the native starch (2.5 times). The disintegration time of 2% w/w pregelatinized arrowroot starch was comparable to Explotab and faster than that of native starch. The disintegration time of native starch at the concentration of 4, 6 and 10 %w/w was comparable to that of corn starch and Explotab®. Native arrowroot starch and pregelatinized arrowroot starch could be used as effective disintegrants in tablet formulation.
Published Version
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