Abstract
AbstractThe modification at the branching of chitosan using 8‐formyl‐7‐hydroxy‐coumarin (ChCm) through chemically cross‐linked has been structured for hydrogel fabrication. ChCm produced stable mechanical properties, improved swelling capacity, and delayed degradation for new cross linking‐functionalized during experimental works. It also imparted high antioxidant potency. The swelling water ratio of this hydrogel makes it robust and elastic, providing a mechanical basis to keep the hydrogel strong and steady. A remarkable self‐fluorescence behavior has been witnessed. The distinct photo‐sensitiveness has been studied thoroughly as time, temperature, and solvent‐dependent spectral analysis to establish the ESIPT mechanism and improve stability in various conditions. Detailed instrumental‐structural evaluations are explored as required, and optimized the gel skeleton and photo activities are using DFT calculations. The effectiveness of radical scavenging using DPPH, antioxidant power using FRAP assay, and chelation ability have been observed during the evaluation of antioxidant potency for hydrogel. The role of phenolic‐OH is very significant not only for optical fluorescence enhancement by ESIPT but also for the improved antioxidant abilities. As well as being less toxic, bio‐compatible, and photostable, it could be used to image fibroblast 3T3 cells by fluorescence; current hydrogel has gained vast potential for developing dynamic biomaterials in multiple applications.
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