Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis

Ezgi Aktaş Karabay,Damla Demir,Aslı Aksu Çerman

doi:10.1016/j.abd.2019.05.002

Ezgi Aktaş Karabay, Damla Demir + Show 1 more

Open Access

https://doi.org/10.1016/j.abd.2019.05.002

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Abstract

BackgroundPsoriasis is a chronic immune-mediated inflammatory skin disease that is associated with cardiovascular comorbidities. ObjectivesThe objective of this retrospective study is to assess the C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio as inflammatory markers in patients with psoriasis and to search for a relationship between these parameters and psoriasis severity, as defined by the psoriasis area and severity index. MethodsThere were 94 patients with psoriasis and 118 healthy controls enrolled in the study. The C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio values of two groups were retrospectively evaluated. ResultsStatistically significant differences were observed in terms of C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio between the patient and control groups (p=0.001, p=0.003, p=0.038, and p=0.007, respectively). Positive correlations were found between the psoriasis area and severity index and the values of C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio (r: 0.381; p<0.01, r: 0.203; p<0.05, r: 0.268; p<0.01, r: 0.374; p<0.01, r: 0.294; p<0.01, respectively). Study limitationsThe small sample size and the retrospective design of the study are limitations. ConclusionElevated C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio were significantly associated with psoriasis. A positive correlation between C-reactive protein and monocyte-to-high-density-lipoprotein ratio leads to the suggestion that monocyte-to-high-density-lipoprotein ratio might be a reliable parameter in psoriasis during the follow-up. The relationship between the diasease and inflammatory parameters might provide early detection of cardiovascular morbidities in psoriasis patients.

Highlights

Psoriasis, a chronic skin disease, is characterized by the infiltration of immune cells into the skin, as well as by abnormal proliferation of keratinocytes.[1]
A total of 94 patients with psoriasis and 118 healthy control subjects were included in the study
No significant differences were observed in the gender ratio or age between the patients with psoriasis and healthy controls (p = 0.393, p = 0.222, respectively)

Summary

Introduction

A chronic skin disease, is characterized by the infiltration of immune cells (e.g., mononuclear leukocytes and neutrophils) into the skin, as well as by abnormal proliferation of keratinocytes.[1]. Levels of C-reactive protein (CRP), which is a wellknown biomarker of inflammation, have been shown to be elevated in patients with psoriasis, indicating cardiovascular comorbidities.[3] The ratio of the monocyte count to high-density lipoprotein cholesterol (MHR) has been demonstrated to be an inflammatory marker, and a new predictor and prognostic factor for CVDs.[4] the neutrophil---lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte---lymphocyte ratio (MLR) have been identified as indicators of systemic inflammation and poor prognosis in a variety of diseases, such as cancer, CVD, and autoimmune inflammatory diseases.5---7 These novel biomarkers have not been well investigated in psoriasis. Study limitations: The small sample size and the retrospective design of the study are limitations

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