Relationship between serum IgE levels and psoriasis area and severity index (PASI) score in psoriasis vulgaris

Abstract

Introduction: Psoriasis is an immune system-mediated inflammatory disorder characterized by skin inflammation, epidermal hyperplasia, and other comorbidities. Based on medical data from H. Adam Malik hospital in 2011, the proportion of psoriasis vulgaris incidence was 0.81%. It is important to assess the severity of the disease. The most frequently used measuring instrument is the Psoriasis Area and Severity Index (PASI) score. Elevated serum IgE levels have been reported in some cases of psoriasis. The relationship between serum IgE levels and psoriasis severity is controversial. The study aimed to determine the relationship between serum IgE levels and PASI scores in psoriasis vulgaris.Method: An observational analytic study with a cross-sectional approach to 37 subjects of psoriasis vulgaris at Haji Adam Malik General Hospital Medan. Patients who meet the criteria are recorded with basic data in personal identity, history taking, physical examination, and dermatological examination. Furthermore, the calculation of the Psoriasis Area and Severity Index (PASI) score and serum IgE levels using ARCHITECT CI8200 with Quantia IgE reagent. The data will be analyzed using SPSS.Results: Psoriasis vulgaris mostly occurs in women (54.1%) with the most age group 31-45 years (40.5%). The median age was 35 years with a range of 21-67 years. The proportion of study subjects with high serum IgE levels (?100) was 26 people (70.3%) with a median of 130 IU/ml and a range of 25-475.5 IU/ml. Based on the PASI score, the highest proportion were subjects with moderate and mild PASI scores as many as 21 people (56.8%) and 13 people (35.1%). The median PASI score was 6, with a range of 0.5 – 10.40. The results of the Pearson correlation test (p) serum IgE levels and PASI scores obtained p-value = 0.0001, which indicated that the relationship between serum IgE levels and PASI scores was significant. The value of the correlation coefficient (r) of 0.909 indicates that the direction of the positive correlation with the strength of the correlation is very strong.Conclusion: There is a relationship between serum IgE levels and Psoriasis Area and Severity Index (PASI) scores in psoriasis vulgaris.