Abstract
Oral submucosus fibrosis (OSMF) is a collagen-related disorder seen in habitual betel quids and smokers. This is a high risk precancerous condition in which the connective tissue fibers of the lamina propria and deeper parts of the mucosa becomes stiff with restricted mouth opening. Patients with severe cases have symptoms like difficulties in chewing, swallowing and speaking. In the present study 25 individuals were gutkha chewers and 25 were OSMF patients (chewing gutkha along with smoking) and 25 individuals were taken as controls. A significant increase in the frequency of micronuclei was observed in OSMF patients (34.4±1.79) as compared to gutkha chewers (14.4±0.73) and controls (4.36±0.27). The number of micronucleated cells in OSMF, gutkha chewers and control groups were 19.84±0.69, 12.6±0.51 and 4.20±0.27, respectively and are significantly different at p<0.05. Acridine orange is used due its fluorescence nature and easier visibility of the micronucleus present in the buccal epithelial cells. It is concluded that chewing gutkha along with smoking is more dangerous for human health as it hastens the incidence of OSMF.
Highlights
The increased popularity of commercially available arecanut types i.e. pan masala and gutkha among young people of India has increased the incidence of oral submucosus fibrosis (OSMF) [1,2]
A significant increase in the frequency of micronucleus was observed in the OSMF patients (34.4 ± 1.79) as compared to gutkha chewers (14.4 ± 0.73) and the control group (4.36 ± 0.27) (Table 1)
The frequency of micronuclei was found to be more in the age group of 25–40 years (Table 3)
Summary
The increased popularity of commercially available arecanut types i.e. pan masala and gutkha among young people of India has increased the incidence of oral submucosus fibrosis (OSMF) [1,2]. OSMF was known in Indian medical literature since the time of Sushruta – a great Indian physician who lived in the era 2500–3000 B.C. OSMF was known in Indian medical literature since the time of Sushruta – a great Indian physician who lived in the era 2500–3000 B.C It was first described in the modern literature by Schwartz and Joshi [3,4]. This disease occurs mostly in South East Asia, but some cases were reported
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