Abstract
Objective: The present study is undertaken to evaluate the effect of Euphorbia neriifolia stem bark on blood glucose and lipid levels in experimental diabetic rats. Methods: Methanolic extract of Euphorbia neriifolia stem bark (MEEN) was administered at different doses and its effect on blood glucose, haemoglobin, serum and tissue lipids, hexokinase and glucose-6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug. Results: Euphorbia neriifolia methanolic extract (MEEN), at doses of 100,200 and 400mg/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Euphorbia neriifolia at 400mg/kg was found to be comparable to glibenclamide. Conclusion: The study indicates that the Euphorbia neriifolia possess antihyperlipidaemic effect as well as antidiabetic activity. Peer Review History: Received 3 May 2017; Revised 5 June; Accepted 1 July, Available online 15 July 2017 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, asia_abdullah65@yahoo.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Mohamed Derbali, Faculty of Pharmacy, Monastir, Tunisia, mohamed.edderbali@gmail.com Dr. Sabah Hussien El-Ghaiesh, Tanta University, Egypt, s.ghaiesh@gmail.com Similar Articles: EVALUATION OF ANTIDIABETIC DRUG ALOGLIPTIN FOR THE TREATMENT OF INFLAMMATION IN RATS IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL EVALUATIONS OF METHANOLIC EXTRACTS OF COCOS NUCIFERA (L.) LEAVES
Highlights
Diabetes mellitus is a principal cause of morbidity and mortality in human populations[1]
Blood glucose and Plasma insulin Table 1 shows the levels of blood glucose, plasma insulin, total haemoglobin, changes in body weight and urine sugar of normal and experimental rats
There was a significant elevation in blood glucose, while the plasma insulin and total haemoglobin levels decreased significantly in streptozotocin diabetic rats when compared with normal rats
Summary
Diabetes mellitus is a principal cause of morbidity and mortality in human populations[1]. It is a syndrome characterized by hyperglycemia, polydipsia and polyuria and causes complications to the eyes, kidneys, and nerves. It is associated with an increased incidence of cardiovascular disease[2]. Diabetes currently affects an estimated 15.1 million people in. It is estimated that globally, the number of people will rise from 151 million in the year 20004, to 221 million by the year 2010, and to 300 million by 20255.
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