Abstract
Objective-Insulin resistance (IR) is an important risk factor for type 2 Diabetes Mellitus (DM2) and cardiovascular disease (CVD). Metabolic Syndrome (MS) is a clustering of metabolic alterations associated to IR; however, there is no international consensus for defining its diagnosis. Our objective was to evaluate the prevalence and characteristics of MS identified by the ATP III and IDF criteria in adults from Talca city.Research and methods-We studied 1007 individuals, aged 18–74, and residents from Talca. MS subjects were defined according to ATP III (three altered factors) and IDF criteria (patients with waist circumference >80/90 cm (W/M) and two others altered factors).Results-The prevalence of metabolic syndrome according to the IDF and ATP III criteria was 36.4% and 29.5%, respectively after adjustment for age and sex. The agreement for both criteria was 89%. The prevalence in men was higher than in women for both MS definitions, although not significant. MS probability increased with age, and the highest risk was in the 57–68 age group (ATP-MS) and 53–72 age group (IDF-MS). Hypertension, high triglycerides and abdominal obesity are the most frequent alterations in MS.Conclusion-MS prevalence in adults was higher when diagnosed with IDF than with ATP criterion; in both, age is directly related with the MS presence. The MS subjects showed higher levels of blood pressure, waist circumference and plasma triglycerides. Considering our results, it is worrisome that one third of our population has a high risk of developing DM2 and CVD in the future.
Highlights
Insulin resistance (IR) is an important risk factor for type 2 Diabetes Mellitus (DM2) and cardiovascular disease (CVD) [1,2,3]
Nutrition Journal 2008, 7:14 http://www.nutritionj.com/content/7/1/14 support the relationship between insulin resistance (IR) and CVD [5,6,7,8]
The progressive increase in obesity, CVD and Metabolic Syndrome (MS) prevalence motivated the National Cholesterol Education Program (NCEP) on its third panel: Treatment of High Blood Cholesterol in Adults (ATP III) [14], to propose clinical criteria to define MS by the presence of at least three altered factors: High blood pressure (BP), hypertriglyceridemia, low HDL cholesterol (HDLc), high plasmatic glucose and abdominal obesity. This definition was simple, so various prospective studies adopted the definition and determined its relation to CVD, but later the NCEP criteria were criticized because the identification of those affected is strongly influenced by ethnicity [15,16,17]
Summary
Insulin resistance (IR) is an important risk factor for type 2 Diabetes Mellitus (DM2) and cardiovascular disease (CVD) [1,2,3]. The progressive increase in obesity, CVD and MS prevalence motivated the National Cholesterol Education Program (NCEP) on its third panel: Treatment of High Blood Cholesterol in Adults (ATP III) [14], to propose clinical criteria to define MS by the presence of at least three altered factors: High blood pressure (BP), hypertriglyceridemia, low HDLc, high plasmatic glucose and abdominal obesity. This definition was simple, so various prospective studies adopted the definition and determined its relation to CVD, but later the NCEP criteria were criticized because the identification of those affected is strongly influenced by ethnicity [15,16,17]. We used SAS 9.1.3, software for statistical analysis
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