Metabolic Syndrome in Preadolescent Girls

Abstract

Endocrinology| November 01 2006 Metabolic Syndrome in Preadolescent Girls AAP Grand Rounds (2006) 16 (5): 54–55. https://doi.org/10.1542/gr.16-5-54 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Metabolic Syndrome in Preadolescent Girls. AAP Grand Rounds November 2006; 16 (5): 54–55. https://doi.org/10.1542/gr.16-5-54 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: metabolic syndrome x, pre-teen Source: Chi CH, Wang Y, Wilson DM, et al. Definition of metabolic syndrome in preadolescent girls. J Pediatr. 2006;148:788–792; doi:10.1016/j.jpeds.2006.01.048 The metabolic syndrome is a clustering of cardiovascular risk factors associated with insulin resistance such as obesity, hyperinsulinemia, dyslipidemia, and hypertension. There is no globally accepted definition of the metabolic syndrome in adults and even less agreement for pediatric patients, thus making it difficult to determine prevalence, compare results from different studies, or agree on screening tests. The purpose of this study was to determine the difference in prevalence rates when applying various published definitions of metabolic syndrome in preadolescent females. Two separate populations from other projects were used. The first was made up of low socioeconomic preadolescent black girls from Oakland, Calif who participated in the Stanford Girls Health Enrichment Multi-site Studies (Stanford GEMS). This was an obesity prevention study of preadolescent girls between the ages of 8 and 10 years with a body mass index (BMI) of ≥50th percentile for age or with a least 1 parent/guardian with a BMI of ≥25 kg/m2. The other population consisted of participants in the Stanford Girls Activity, Movement, and Environmental Strategy study (Stanford GAMES) in which preadolescent females, 7–10 years old, from 6 ethnically and socioeconomically diverse public elementary schools in South San Francisco, were enrolled for an obesity prevention study. Girls were ineligible in both studies if they had a prior diagnosis of diabetes mellitus, a chronic illness that affects growth or weight, or they received a medication potentially affecting growth or weight. Study parameters followed included weight, height, waist circumference, triceps skinfold, and resting systolic and diastolic blood pressure. Laboratory measurements included plasma glucose, insulin levels, HDL cholesterol, and triglyceride values. Investigators for studies on youth have used various sets of modified adult criteria to estimate the prevalence of metabolic syndrome in pediatric populations. Studies published in the past decade were reviewed to identify different sets of criteria for defining metabolic syndrome in children and adolescents. These studies were subsequently divided into projects using criteria adapted from the National Cholesterol Education Program Adult Treatment Panel III (ATP III)1 or World Health Organization (WHO)2 definitions of metabolic syndrome (6 and 8 projects, respectively). As an example of the range of definitions, one WHO-based definition requires BP ≥90% for age and sex, triglycerides or total cholesterol ≥90% for age and sex, and fasting glucose ≥90% for age and sex, while another requires insulin resistance (≥75% insulin for age and sex) plus 2 of these risk factors: systolic BP ≥75% for age and sex; HDL ≤25% for age and sex; glucose ≥110 mg/dL; and BMI ≥85% for age and sex. Prevalence of the metabolic syndrome ranged from 0.4% to 23% for GEMS and 2.0%–24.6% for GAMES using the definitions adapted from ATP III. There was a wide range of prevalence for metabolic syndrome, between 0%–15.3% for GEMS and 0.4%–15.8% for GAMES, when modified WHO criteria were used to define metabolic syndrome in the... You do not currently have access to this content.