Abstract
2full factorial design was employed for the optimization of developed formulation. The developed formulations showed uniform appearance, average weight, drug content and adequate hardness. The increase in lag time was observed with an increase in HPMC concentration and decreased concentration of a superdisintegrant. Further comparison of Luffa aegyptica mill powder in the concentration suggested in the optimized formulation with pharmaceutically acceptable superdisintegrant in same concentration showed equivalent drug release behavior. It can be concluded from the outcome of the present research that Luffa aegyptica mill powder, a natural superdisintegrant, can prove to be best alternative to the existing superdisintegrants.
Highlights
pulsatile drug delivery system (PDDS) is such system where drug is released suddenly after well-defined lag time or time gap according to circadian rhythm of a particular disease states
The increase in lag time was observed with an increase in HPMC concentration and decreased concentration of a superdisintegrant
The pulsatile system described consists of two different components, the central rapid release core tablet made up of drug, superdisintegrant and other directly compressible excipients and external barrier layer consisting of PVP K30 and HPMC K4M
Summary
PDDS is such system where drug is released suddenly after well-defined lag time or time gap according to circadian rhythm of a particular disease states. Very negligible amount of drug or no drug is permitted to be released from the device during the lag time. Compression coating is a technique that does not require any solvents or special equipment’s for coating of the dosage form and coating can be done faster and even avoiding environmental hazards. In this technique a previously compressed core tablet is further coated using different polymeric barriers by multiple compressions. This system delivers the drug from the core tablet after swelling/erosion of the hydrophilic or hydrophobic barrier of the coating shell and may exhibit a pulsatile release of the drug [9,10,11,12,13,14]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
