Evaluation of left ventricular mechanical dyssynchrony in patients with heart failure using a novel Cadmium-Zinc-Telluride single photon emission computed tomography

Abstract

Objective The aim of this study was to evaluate left ventricular systolic asynchronization in patients with heart failure by gated myocardial perfusion imaging(GMPI)using Cadmium-Zinc-Telluride(CZT)single photon emission computed tomography(SPECT), and compare with conventional SPECT myocardial perfusion imaging(MRI) and positron emission tomography(PET)assessment. Methods Thirty-five consecutive patients with heart failure were recruited from July to October 2016 in Fuwai hospital.All patients underwent CZT SPECT GMPI, conventional SPECT GMPI, PET and cardiac MRI within 7 days.Bind width(BW)and standard deviation(SD)were calculated by three nuclear medicine imaging modalities. Results CZT SPECT GMPI showed good correlation respectively for BW(r=0.833, P<0.001)and SD(r=0.795, P<0.001)with conventional SPECT GMPI.CZT SPECT GMPI also showed a good correlation respectively for BW(r=0.914, P<0.001)and SD(r=0.804, P<0.001)with PET.Bland-Altman analysis revealed good agreement of BW and SD between CZT SPECT and PET.Bland-Altman analysis showed systematic underestimation of BW and SD with conventional SPECT GMPI compared with CZT SPECT and PET. Conclusion CZT SPECT GMPI with minimal acquisition time provides the left ventricular dyssynchrony parameters that correlated well and had good agreement with PET, and has the high value of clinical application in patients with heart failure. Key words: Heart failure; Cadmium-Zinc-Telluride; Single photon emission computed tomography; Dyssynchrony