Evaluation of learning memory activity of Unmad Gaja Kesari Rasa II in Animal Models

Abstract

In recent era there is competition in each and every field, so there is lot of mental stress or mental disorder seen. In modern medicine there are various drugs such as antipsychotic, antiepileptic, mood stabilizer etc. which have certain adverse effect such as drowsiness, dizziness, memory loss etc. But Ayurveda certainly has an answer, there are total 112 formulations mentioned in classical text for physco neurological disorder i.e., Unmad and Apasmar, out of these there are total 25 herbo-mineral formulations and Unmad Gaja Kesari Rasa II (UGK II) is one of them. Present study was done to evaluate Learning memory effect of Unmad Gaja Kesari Rasa II a herbo-mineral compound. Cook’s and widely model was used to evaluate learning memory activity. Total 30 wistar rats were classified into 5 groups each containing 6 rats. Human dose was extrapolated with extrapolating factor 0.018 and drug dose was given to control I and II, standard, test x and 2x group, after that learning and Relearning trails were given and avoidance, escape and no response was observed. It has been established that UGK II (Rasa Kamdhenu i.e.; R.K Unmad Chikitsa/9-12) has effective role in learning and memory activity.