Abstract
Microspheres (MS) of Ketorolac Tromethamine (KT) for oral delivery were prepared by complex coacervation (method-1) and simple coacervation (method-2) methods without the use of chemical cross–linking agent (glutaraldehyde) to avoid the toxic reactions and other undesirable effects of the chemical cross-linking agents. Alternatively, ionotropic gelation was employed by using sodium-tripolyphosphate (Na-TPP) as cross linking agent. Chitosan and gelatin B were used as polymer and copolymer respectively. All the prepared microspheres were subjected to various physico-chemical studies, such as drug-polymer compatibility by Thin Layer Chromatography (TLC) and Fourier Transform Infra Red Spectroscopy (FTIR), surface morphology by Scanning Electron Microscopy (SEM), frequency distribution, encapsulation efficiency, in-vitro drug release characteristics and release kinetics. The physical state of drug in the microspheres was determined by Differential Scanning Calorimetry (DSC) and X-ray powder Diffractometry (XRD). TLC and FTIR studies indicated no drug-polymer incompatibility. All the MS showed release of drug by a fickian diffusion mechanism. DSC and XRD analysis indicated that the KT trapped in the microspheres existed in an amorphous or disordered-crystalline status in the polymer matrix. It is possible to design a controlled drug delivery system for the prolonged release of KT, improving therapy by possible reduction of time intervals between administrations.
Highlights
The present study reports a novel attempt to prepare complex coacervates of chitosan and gelatin B as carriers for the widely used Non-Steroidal Anti Inflammatory Drug (NSAID) Ketorolac tromethamine
Ketorolac tromethamine MS were prepared by emulsion-phase separation technique without the use of chemical cross-linking agents: to avoid the toxic and undesirable effects such as loss of protein bioactivity, neurotoxicity of chemical cross-linking agents
It can be seen that the solution pH may play an important role on the chitosan microsphere formation [16]
Summary
The present study reports a novel attempt to prepare complex coacervates of chitosan and gelatin B as carriers for the widely used Non-Steroidal Anti Inflammatory Drug (NSAID) Ketorolac tromethamine.Ketorolac tromethamine is a potent non narcotic analgesic with moderate antiinflammatory activity. The present study reports a novel attempt to prepare complex coacervates of chitosan and gelatin B as carriers for the widely used Non-Steroidal Anti Inflammatory Drug (NSAID) Ketorolac tromethamine. Evaluation of Ketorolac Tromethamine Microspheres by Chitosan/Gelatin B Complex Coacervation 81 The KT microspheres were prepared by complex coacervation technique by using chitosan/gelatin B mixture as coating material.
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