Abstract
Systemic lupus erythematosus (SLE) is a major cause of cardiovascular mortality and morbidity associated with early atherosclerosis. Carotid intima-media thickness (CIMT) is one of the early markers of atherosclerosis. Oxidative stress plays an important role in pathophysiologic mechanisms of SLE. Ischemia modified albumin (IMA) and total oxidant status (TOS) have been associated with oxidative stress in several diseases. In our study we aimed to investigate the relationship between serum IMA and TOS levels with CIMT in patients with SLE and to compare these with control group values. In our study, 60 SLE patients diagnosed according to the American College of Rheumatology (ACR) criteria and 35 healthy controls were included. Serum IMA levels were measured by manually spectrophotometric method. Increased serum TOS and IMA levels and CIMT were found in patients with SLE when compared with control group (p 0.05). Our results suggest that serum levels of IMA and TOS increase in SLE. However lack of association between the tested parameters suggests that further researches are needed.
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