Abstract
Extracorporeal circulation (ECC) methods are being increasingly used for mechanical support of respiratory and cardio-circulatory failure. Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patient’s life by providing an appropriate blood flow and oxygen supply to principal organs. On the other hand, systemic inflammatory responses in patients undergoing cardiovascular surgery supported by CPB contribute significantly to CPB-associated mortality and morbidity. Our previous research showed that CPB causes a systemic inflammatory response and organ damage in a small animal CPB model. We have been studying the effects of hyperoxia and blood plasma substitute on CPB. In this review, we present a study focusing on the systemic inflammatory response during CPB, along with our findings.
Highlights
Extracorporeal circulation (ECC) methods are being increasingly used for mechanical support of respiratory and cardio-circulatory failure
The present study proved that the pro-inflammatory cytokines significantly increased more in
The present study proved that the pro-inflammatory cytokines significantly increased more in the high oxygen partial pressure condition cardiopulmonary bypass (CPB) [25]
Summary
Extracorporeal circulation (ECC) methods are being increasingly used for mechanical support of respiratory and cardio-circulatory failure. Until the 1950s, cardiovascular surgery had a very high mortality and morbidity rate. This situation changed due to the development of the CPB system by Dr Gibbon [2] and body surface cooling for hypothermia by Dr Gordon [3]. Cardiovascular surgery with CPB is often associated with a systemic inflammatory response syndrome, significantly affecting the postoperative mortality and morbidity [1,4,5]. The inflammatory response caused by CPB is known to especially affect humans [6,7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
