Abstract
Objective: The present study was intended to evaluate the in vivo immunomodulatory activity of aqueous and ethanolic extract of dried fruits of Capparis moonii Wight. 
 Methods: The effect of both the extracts was evaluated by carbon clearance assay in mice, and they showed a significant increase in the phagocytic index at 50, 100, and 200 mg/kg dose. The effect of the extracts on delayed-type hypersensitivity (DTH) and antibody titer assay was evaluated in ovalbumin immunized mice.
 Results: Both extracts showed a significant effect on DTH response and stimulation of antibody titer at 200 mg/kg dose. The effects of the extracts in cyclophosphamide-induced myelosuppression mice were also statistically significant.
 Conclusion: The studies demonstrated specific and non-specific immunostimulating properties of both the ethanol and aqueous extract of C. moonii fruits in various in vivo experimental methods suggesting its therapeutic usefulness in immunocompromised conditions.
Highlights
Immunomodulation is a transition in the immunological network of the body and an immunomodulator would be the agent which can interfere with this immunological network to stimulate or suppress certain characteristics of the host response [1,2]
The powder was extracted with ethanol under soxhlation to give an ethanolic extract of fruits of C. moonii (CME) and with water under soxhlation to give an aqueous extract of fruits of C. moonii (CMA)
In vivo model for phagocytic activity using the carbon clearance assay The result of CMA and CME extract was determined by the clearance assay in animals
Summary
Immunomodulation is a transition in the immunological network of the body and an immunomodulator would be the agent which can interfere with this immunological network to stimulate or suppress certain characteristics of the host response [1,2]. Developing agents that can move the immune system of the patient from a state of immune deficiency to one of the more normal functions would likely have a major effect on the disease and the patient. The family of Capparaceae consists of several essential medicinal characteristics, which is found to be distributed in tropical and subtropical India Plants pertaining to this family were characterized as Rasayana herbs and are used widely as an adaptogen to boost non-specific antioxidant resistance and immunostimulation effects. Curative uses of Rudanti in Ayurveda: Rudanti nurtures each and every cell of the body (Rasayani) It is effective under dietary and emaciating (Shoshghani) situations. Thomas ethanolic extract of was tested for hepatotoxicity in rats caused by carbon tetrachloride (CCl4). Carbon-tetrachloride-mediated hepatotoxicity prevention by C. moonii ethanolic extracts in rats was observed [11]. The primary goal of this research was to determine the in vivo immunomodulatory activity of C. moonii’s aqueous and ethanolic extract
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
