EVALUATION OF IMMUNOMODULATION ACTIVITY OF SOMANATHI TAMRA BHASMA

Abstract

Somanathi Tamra Bhasma is a special method of preparation of t amra b hasma by using shudha t amra, parada, gandha ka, haritala and manashila and which is considered as more effective and less toxic. Tamra possess properties like brimhana, pramehagna and hridya. Therefore it is expected t o have immunomodulatory effect. Evaluation of Immunomodulation activity of s omanth i t amra b hasma was carried out in S.D.M. Centre for Research in Ayurveda and Allied Science Udupi , Karnataka, India through animal experimentation. Effect of s omanathi t amra b hasma on cell mediated Immunity were evaluated by using Immunological paw edema m ethod in albino rats and effect of s omanathi t amra b hasma on humoral antibody formation were evaluated by noting Antibody titer and Biochemical, Haematological, and Histopathological findings. Analysis of the results obtained from the Immunomodulation stud y, clearly shown that, the test drug s omanathi t amra b hasma has CMI suppression effect. This effect is produced without affecting anti - body formation indicating specific nature of the observed effect. It is suggested that this effect may be due to modulati on of the Th - 1 pathway of adaptive immune reaction. H a ematological parameter assessment did no t reveal any remarkable change. Among the biochemical parameters elevation of SGOT was observed after SRBC injection and was moderately reversed by the test formu lation. Thus it can be suggested that this formulation can be employed in clinical conditions involving inappropriate increase in CMI.