Evaluation of Hydro-alcoholic extract of Corchorus capsularis seeds for its Anti-ulcer activity on Albino Wistar Rat

Abstract

The objective of present study was to evaluate the anti-ulcer activity of hydro-alcoholic extract of Corchorus capsularis seeds. Mainly hyper secretion of gastric acid and pepsin causes ulcer in patients. Plant extracts and polyherbal formulations are two of the most appealing sources of new drug. This type of extract formulations are showing good results in the treatment of gastric ulcers. In this study anti-ulcer activity was investigated by pyloric ligation, aspirin and stress induced gastric ulcer in albino wistar rats. The extract was given at the dose of 250mg/kg (CCLD- Corchorus capsularis low dose) and 500mg/kg (CCHD- Corchorus capsularis high dose) in all the experimental models. Ranitidine (150mg/kg) was used as standard drug. CCLD and CCHD showed 37.49% and 63.14% ulcer inhibition respectively, whereas ranitidine 69.69% against pylorus ligation induced ulcer. In aspirin induced ulcer model the extract showed ulcer inhibition 48.64% and 64.00% in CCLD and CCHD respectively whereas the standard drug ranitidine exhibited 84.64% ulcer inhibition. In stress induced ulcer model CCLD, CCHD and ranitidine exhibited 48.64%, 64.00% and 84.64% ulcer inhibition respectively. In all the models ethanolic extract of Corchorus capsularis seeds has shown significant anti-ulcer activity in dose dependent manner.