Abstract
Background:Breast cancer (BC) is the most common malignancy in Iraqi women in the recent years. There are many indicated marker for detection BC and determination the development of the tumor stage, one of the most important marker is human epidermal growth factor receptor-2 (HER2). Objective:To evaluation of serum and tissue HER2 levels among BC women and non BC women. Patients and Methods: Preoperative blood samples were collected from breast cancer women. Patients were newly diagnosing and did not receive neither radiotherapy nor chemotherapy treatment preoperatively.For the control, blood sample was collected from non-breast cancer women. All blood samples subjected to determine the serum HER-2 level. Results: A total of 52 patients with breast cancer and 30 of control were included in this study. The result showed increasing significant in serum concentration of HER-2 among BC patient compared to control and tissue her-2 positive BC patient have significantly higher serum concentration of HER-2 compared to BC patients who were tissue her-2 negative (16.23±10.37 ng/ml, 10.33±5.73 ng/ml) respectively. Conclusion: Serum HER-2 level was positively associated with tissue HER-2 level, for that is an important marker for diagnosis and monitoring BC progression.
Highlights
Breast cancer is the most common type of malignancy recorded in the cancer registries of almost all countries within the Eastern Mediterranean Region
Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast Cancer factors: postmenopausal obesity, use of postmenopausal hormones, alcohol consumption, physical activity, and smoking are modifiable risk factors [3].Human epidermal growth factor receptor-2 is more intensively studied in Breast cancer (BC) and other solid cancers Firstly identified by Schechter 1984 [4]
It is consisting of three principle domains the first is the extracellular ligand binding domain (ECD), the second, is the transmembrane domain (TMD) and the third, the intracellular tyrosine kinase catalytic domain (ICD) [5]
Summary
Breast cancer is a multifactorial disease there are a number of risk factors that affected the probability of developing BC; several factors like (gender, age, personal history, family history, early menarche and late menopause) are not modifiable.Other factors: postmenopausal obesity, use of postmenopausal hormones, alcohol consumption, physical activity, and smoking are modifiable risk factors [3].Human epidermal growth factor receptor-2 is more intensively studied in BC and other solid cancers Firstly identified by Schechter 1984 [4].
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