Evaluation of Herbal Mouthwashes Containing Zataria Multiflora Boiss, Frankincense and Combination Therapy on Patients with Gingivitis: A Double-Blind, Randomized, Controlled, Clinical Trial.

Zoleikha Khoshbakht,Farzaneh Lotfipour,Ehsan Khashabi,Mohammad Ali Torbati,Laleh Khodaie,Hamed Hamishehkar

doi:10.31661/gmj.v8i0.1366

Zoleikha Khoshbakht, Farzaneh Lotfipour + Show 4 more

Open Access

https://doi.org/10.31661/gmj.v8i0.1366

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Abstract

Background: Dental plaques as adhesive microbial aggregates on tooth surfaces are considered the first stage of tooth decay as well as gingivitis. Accordingly, the effect of different antimicrobial mouthwashes on removing dental plaques and preventing their formation has been evaluated in various studies. This study aimed to evaluate the efficacy of herbal mouthwashes containing hydro-alcoholic extract of Zataria multiflora (ZM), Frankincense (FR), and a combination of both (ZM+FR) and compare it with chlorhexidine (CHX) mouthwash in subjects with gingivitis. Materials and Methods: In this randomized, controlled, clinical trial a total of 140 patients with gingivitis were divided into four groups including CHX (control group), ZM, FR, and ZM+FR groups. Plaque index (PI), gingival index (GI), and gingival bleeding index (GBI) were measured in days 1, 14, and 21. Results: All three herbal types of mouthwash significantly improved plaque, gingivitis, and gingival bleeding throughout days 14 to 21 (P<0.001). There was no difference between herbal mouthwash with CHX groups. CHX mouthwash showed the most side effects (54.3%), while ZM mouthwash showed the least side effects and the highest consumer satisfaction (5.7% and 94%, respectively). Conclusion: All of the herbal mouthwashes can be good candidates for controlling gingivitis. Comparing with CHX mouthwash, herbal mouthwashes have lower side effects and negligible alcohol content. Among the herbal mouthwashes, ZM outperforms FR and FR+ZM due to its lower side effects and higher levels of patients’ satisfaction.

Highlights

Gingivitis is a mild and reversible inflammation of the gingival tissue that manifests with symptoms such as erythema, edema, and spontaneous or provoked bleeding [1]
Frankincense (FR) is a fragrant gum resin derived from Boswellia tree belonging to the Burseraceae family [19]
This study aimed to evaluate the clinical efficacy of Zataria multiflora (ZM), FR, and ZM+FR mouthwashes and compare it with CHX mouthwash for improving gingival health considering related indices and patient’s satisfaction

Summary

Introduction

Gingivitis is a mild and reversible inflammation of the gingival tissue that manifests with symptoms such as erythema, edema, and spontaneous or provoked bleeding [1]. In traditional Iranian pharmacopeia called “Qarabadine,” more than 50 medicinal plants in forms of gargle, mouthwash, powder, and oral douches have been recommended to treat oral and dental problems [12, 13] In these formulations, plants such as Salvadora persica, Aloe vera, Acacia arabica, Bunium persicum, Rosa damascena, and Rhus coriaria were used either alone or in combination with other materials [2].Zataria multiflora Boiss (ZM) belongs to the Lamiaceae family and is native to central and southwest Asia. Despite being not native to Iran, this plant is known to traditional medicine therapists It has been used in forms of mouthwash and powder for preventing gingival bleeding and halitosis and healing gingival wounds [12]. This study aimed to evaluate the clinical efficacy of ZM, FR, and ZM+FR mouthwashes and compare it with CHX mouthwash for improving gingival health considering related indices and patient’s satisfaction

Materials and Methods

Results

Conclusion