Abstract
Objective: The present study was conducted to determine the hepatoprotective potentials of methanol s extracts of Tephrosia villosa leaves against thioacetamide (TAA) induced liver damage in rats. Methodology: The acute oral toxicity study was conducted as per OECD guidelines, and the extract was proved to be safe up to the dose of 2000 mg/kg. The total duration of the study was 21 days, and animals were divided into six groups. Hepatotoxicity was induced in the animals of all groups except normal control by single dose administration of TAA (100 mg/kg) at 1st day of the study followed by animals were treated daily with standard drug silymarin and methanol extract of T. villosa (100 mg/kg, 200 mg/kg and 400 mg/kg) to respective groups for 21 days. Variations in biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, direct bilirubin, albumin, total protein, ions and others parameters such as clotting time and weight of the liver were considered to determine beneficial effect of the extract. At the end of the study liver samples were collected and subjected to histopathological evaluation. Results: In control animals treated with TAA alone, there were variations in the above mentioned parameters. However in the animals treated with methanol extract and standard drug silymarin, all the parameters were normal possibly due to their beneficial property in protecting the liver against TAA induced hepatotoxicity. Conclusion: The results obtained in the above study suggesting that, the methanol extract of T. villosa possess significant hepatoprotective activity.
Highlights
The liver disorder has become one of the common health problems worldwide due to exposure human life to various drugs, alcohol, toxins, and hepatitis viral infections [1]
The results obtained in the above study suggesting that, the methanol extract of T. villosa possess significant hepatoprotective activity
The liver has got its own importance in the physiological system such as metabolism of ingested substances such as carbohydrates, lipids, proteins, blood coagulation, detoxification process, and immunomodulation are the primary functions of the liver [1]
Summary
The liver disorder has become one of the common health problems worldwide due to exposure human life to various drugs, alcohol, toxins, and hepatitis viral infections [1]. Liver is vital organ of biliary system required to maintain important homeostasis of the body due its various responsibilities. The liver has got its own importance in the physiological system such as metabolism of ingested substances such as carbohydrates, lipids, proteins, blood coagulation, detoxification process, and immunomodulation are the primary functions of the liver [1]. The liver injury is associated with distortion of these metabolic functions [2] and results into disturbance in homeostasis of the body. Till there is no truly satisfactory liver protective drug in the modern system of medicine which is effective and safe. Natural remedies from medicinal plants are considered to be effective and safe alternative drugs for the treatment of hepatotoxicity and a number of medicinal plants in Ayurveda, the Indian system of medicine, are recommended for the treatment of liver disorders [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Pharmaceutical and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
