Abstract
<p>The objective of the present study was to evaluate methanolic extract of leaves of Waltheria indica linn. for hepatoprotective potency of the potent solvent extract. The hepatotoxicity was induced by diclofenac, carbon tetrachloride (CCl 4 ) and acetaminophen. In CCl 4 induced hepatotoxicity study, animals were divided into five groups (n=6). Methanolic extract of Waltheria indica (WIM) groups were injected in doses of 400 mg/kg and 600mg/kg body weight along with CCl 4 and Silymarin 100mg/kg was taken as standard drug. Similarly procedure was followed in diclofenac and acetaminophen induced hepatotoxicity. Blood samples and liver were collected and liver hisopathological studies were carried out. These histopathological analysis suggested that WIM extract have the ability to reduce the degree of hepatic fibrosis induced by various factors. And concluded that WIM extract has significant hepatoprotective activity thus this study scientifically support the theory to use of this plant in traditional medicine for the treatment of liver disorders.</p>
Highlights
The liver is a versatile organ which is responsible for the metabolism of chemicals and for the regulation of internal chemical environment
Liver functions as a centre of metabolism of nutrients such as carbohydrates, proteins and lipids and excretion of waste metabolites. It handles the metabolism and excretion of drugs and other xenobiotics from the body thereby providing protection against foreign substances by detoxifying and eliminating them [1].The liver is a major target organ for toxicity of xenobiotics and drugs, because most of the orally ingested chemicals and drugs first go to liver where they are metabolized into toxic intermediates
In the group treated with diclofenac, total protein and albumin depleted and were significantly decreased (P < 0.001) when compared with the normal control group
Summary
The liver is a versatile organ which is responsible for the metabolism of chemicals and for the regulation of internal chemical environment. Liver functions as a centre of metabolism of nutrients such as carbohydrates, proteins and lipids and excretion of waste metabolites. It handles the metabolism and excretion of drugs and other xenobiotics from the body thereby providing protection against foreign substances by detoxifying and eliminating them [1].The liver is a major target organ for toxicity of xenobiotics and drugs, because most of the orally ingested chemicals and drugs first go to liver where they are metabolized into toxic intermediates. Hepatotoxicity from NSAIDs can occur at any time after drug administration, but like most adverse drug reactions, most commonly occurs within 6–12 weeks of initiation of therapy
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