Abstract
The effect of the ethanolic extract of the leaves of Capparis sepiaria Linn was studied against carbon tetrachloride-induced hepatotoxicity in Wister rats. Significant hepatoprotective effects were obtained in liver damage induced by carbon tetrachloride as evident from decreased serum levels of glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP) and bilirubin (SB) in the Capparis sepiaria (CS) treated groups (100,200 mg/kg), compared to the intoxicated controls. The hepatoprotective effect was further confirmed by histopathalogical studies of the liver, which showed improved architecture, absence of nuclear pycnosis, hepatocyte congestion and necrosis, when compared with the liver of the toxin group of animals. Capparis sepiaria (CS) extract also showed significant free radical scavenging activity In Vitro. Thus the present study provides a scientific rationale for the traditional use of this plant in the management of liver disorders.
Highlights
Capers, comprising of species of the genus capparis Linn. are reported to have many medicinal properties
Group॥, the carbon tetrachloride intoxicated control group received a daily dose of 0.5% gum acacia for 4 days and 0.3ml/kg (Carbon Tetrachloride mixed with an equal volume of liquid paraffin) on day 3, 30 min after capparis sepiaria (CS) administration
Group V animals received a daily dose of Silymarin (Sigma Chemical Company, U.S.A) at a dose of 100 mg/kg p.o., for 4 days 0.3ml/kg (Carbon Tetrachloride mixed with an equal volume of liquid paraffin and, p.o.,), 30 min after Silymarin administration by mild ether anesthesia
Summary
Capers, comprising of species of the genus capparis Linn. (familycapparaceae) are reported to have many medicinal properties. (familycapparaceae) are reported to have many medicinal properties They reduce flatulence and have anti-rheumatic effects in ayurvedic medicine; capers are recorded as hepatic stimulants and protectors, improving liver function. They have been used to treat arteriosclerosis, as diuretics, kidney disinfectants, vermifuges, and tonics. Infusions and decoctions from caper root bark have been traditionally used for dropsy, anemia, arthritis and gout. They contain considerable amounts of the antioxidant bioflavonoid, rutin. Capparis spinosa Linn is used in splenic, renal and hepatic complaints. The potent hepatoprotective effects of C.spinosa have already been reported.[2]
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