Abstract
BackgroundOverproduction of reactive oxygen species as a result of hyperglycemia in diabetes mellitus leads to microvascular complications. Glutathione S-transferases play important detoxifying roles with antioxidant potentials. This study aimed to assess whether the glutathione S-transferase M1 and T1 genotypes were associated with type 2 diabetes mellitus microangiopathic complications in the Iranian population.ResultsIn this case-control study, the frequencies of null GSTM1 and GSTT1 genotypes were 4/72 (5.56%) and 12/72 (16.67%) respectively, in uncomplicated DM group. The frequencies of null GSTM1 and GSTT1 genotype in complicated DM group were 16/134 (11.94%) and 37/134 (27.61%), respectively. The proportion of GSTM1 null genotypes was higher in diabetic nephropathy compared to non-nephropathy (19.3% vs. 6.04 %, P = 0.006). At GSTT1 locus, patients with diabetic peripheral neuropathy had a higher frequency of deletion compared to those of without neuropathy (30.39% vs. 23.49%) (P = 0.02).ConclusionSelective polymorphisms encoding GSTM1 and GSTT1genes may prove useful as genetic markers to recognize individuals with an increased trend in developing diabetic nephropathy and neuropathy, respectively. This will help better identify individuals at higher risk toward microvascular complications of type 2 diabetes due to genetic susceptibility.
Highlights
Overproduction of reactive oxygen species as a result of hyperglycemia in diabetes mellitus leads to microvascular complications
A dataset of two hundred-six type 2 diabetes (T2D) patients and 114 diabetes-free participants were included in this study
Analysis of the distribution by age and sex proved no significant differences between the study groups; homogeneity between groups was observed
Summary
Overproduction of reactive oxygen species as a result of hyperglycemia in diabetes mellitus leads to microvascular complications. This study aimed to assess whether the glutathione S-transferase M1 and T1 genotypes were associated with type 2 diabetes mellitus microangiopathic complications in the Iranian population. Hyperglycemia in type 2 diabetes (T2D) may lead to overproduction of reactive oxygen species (ROS) in the cells which in turn activates protein kinase (PKC), Hashemi-Soteh et al Egyptian Journal of Medical Human Genetics (2020) 21:40 two indifferent mutations (GSTM1a and GSTM1b) [10, 11]. We aimed to determine the genotype frequency of the GSTM1, GSTT1 polymorphisms to understand whether or not the GST polymorphisms are associated with a higher risk for microvascular complications related to DM in Iranian population
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