Abstract
Background: Glutathione S‐transferases (GSTs) are a family of multifunctional enzymes playing an important role in the cellular detoxification. Therefore, diminished expression of GSTs may result in a reduced body defense against oxidative stress, followed by development of diabetic complications.Aim: To test the hypothesis that the loss of activity of the GSTs enzyme due to deletion polymorphism in GSTT1 and/or GSTM1 may affect the risk of developing complications in DM and to study the other risk factors for complications in DM.Methods: 150 non‐complicated type 2 diabetic patients and 150 complicated type 2 diabetic patients were enrolled in the study. The GSTM1 and GSTT1 genotypes were identified by polymerase chain reaction of peripheral blood DNA samples. Analysis of data was done by using SPSS program.Results: The frequencies of null GSTM1 and GSTT1 genotypes were 53.3% (80/150) and 40% (60/150) respectively in non‐complicated DM group. The frequencies of null GSTM1 and GSTT1 genotype in complicated DM group were 57.3% (86/150) and 58% (87/150) respectively. The null GSTT1 genotype showed statistically significance higher rate in complicated DM compared with non‐complicated DM.Conclusion: Our data provide evidence that diabetics with null GSTT1 genotypes are substantially at higher risk for developing complications.
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