Evaluation of glucagon-like peptide-1, adropin, and desnutrin levels, and related factors in patients with bipolar disorder

Abstract

Objective: It is known that impaired energy metabolism contributes to the neuropathology of bipolar disorder (BD). Our aim in this study was to compare the levels of glucagon-like peptide-1 (GLP-1), adropin and desnutrin, which have many metabolic functions after the regulation of energy metabolism in patients with bipolar disorder and those in healthy controls, and to investigate the related factors. Methods: To the study group of the research, 73 age- and sex-matched people were included. Of them, 35 were patients diagnosed with BD, and 38 were healthy individuals. In the blood samples, in addition to routine biochemistry lipid parameters, the levels of adropin, desnutrin and GLP-1 were determined. Results: Adropin, desnutrin and GLP-1 levels were significantly lower in the patients with bipolar disorder than were those in the healthy controls. On the other hand, Body mass index, total cholesterol, triglyceride, low density lipoprotein values were significantly higher in the patients with BD than were those in the healthy controls (p