Difference of serum adipokine and glucagon like peptide -1 in stable coronary heart disease patients with normal body weight and obesity

Abstract

Objective To compare the the levels of serum adipose factors and glucagon like peptide -1 (GLP-1) in patients with stable coronary artery disease(SCAD) and different body mass index(BMI). Methods From August 2011 to December 2013, seventy-nine patients with stable coronary artery disease (SCAD, n=79) undergone coronary angiography and controls with matched age and sex (n=80) in Beijing Anzhen Hospital, Capital Medical University with stable coronary heart disease with normal body mass and obesity confirmed by coronary angiography (CAG) were selected, and eighty non CHD patients confirmed by age and sex matched by CAG were selected as the control group.According to the body mass index (BMI) and the diagnosis of coronary heart disease, the subjects were divided into normal group (n=40, BMI=18.5-24 kg/m2), obesity group (n=40, weight≥28 kg/m2), SCAD group (n=39) and obesity SCAD group (n=39). The levels of TNF-α, HMW-APN, Irisin, FGF-21, GLP-1, Apelin were measured by enzyme-linked immuno sorbent assay (ELISA). Results The serum GLP-1 and HMW-APN level of obesity participants was (18.50±5.27)ng/L, (3.85±1.59) mg/L, much lower than those in non-obesity participants ((20.35±5.5)ng/L, ( 4.57±2.01) mg/L( P<0.05). The serum GLP-1 level of obesity SCAD group ((17.59±5.13)ng/L) was also lower than that in SCAD group ((21.21±5.06) mg/L) (P<0.05). The level of FGF-21 was negatively correlated with fasting blood glucose (r=-0.169, P<0.05). Conclusion The decrease of GLP-1 level was associated with obesity and stable coronary heart disease.Irisin, FGF-21 and Apelin were found to have no predictive value for obese patients with stable coronary heart disease Key words: Adipokines; stable coronary heart disease; obesity; glucagon like peptide -1