Evaluation of Glifeet in bowel preparation before colonoscopy

Abstract

Objective To investigate the safety and effectiveness of Glifeet in bowel preparation before colonoscopy. Methods A prospective, single blind, randomized controlled trial of patients undergoing colonoscopy was conducted. A total of 67 inpatients were randomized to the control group, who received a low-residue and semiliquid diet (n=31) and the experimental group, who received Glifeet all day (n=36) before the procedure. All patients took polyethylene glycol electrolyte powder 1 000 ml at 7 pm on the day before colonoscopy and 2 000 ml at 8 am on the examination day. Bowel preparation quality was scored using the Boston Bowel Preparation Scale (BBPS). Side effects were also observed. Results The time of the first bowel movement of the experimental group was significantly shorter [(77.43±54.21) min VS (149.35±118.15) min, P=0.002]. An increased defecating frequency was observed in the experimental group, but there was no significant difference when compared with the control group (11.44±6.95 VS 8.74±3.58, P=0.055). Patient tolerance and acceptance did not differ. There was no significant difference in BBPS between the two groups. But the bowel preparation quality of the right colon was significantly better in the experimental group (2.56±0.50 VS 2.23±0.81, P=0.045). Conclusion Glifeet could meet the needs of basic energy in most patients for colonoscopy. Furthermore, Glifeet is well tolerated and can partially improve the quality of bowel preparation. Key words: Colonoscopy; Bowel preparation; Diet; Polyethylene glycols