Effects of prucalopride combined with polyethylene glycol electrollytes powder in bowel preparation for colonoscopy in 124 elderly patients

Abstract

Objective To evaluate the colon cleaning efficacy and safety of prucalopride combined with polyethylene glycol electrollytes powder in bowel preparation for colonoscopy examination and treatment under colonoscopy in elderly patients. Methods Elderly patients who prepared for colonoscopy were enrolled from October 2014 to January 2015. They were divided into group A, B and C. Patients of group A only took polyethylene glycol electrolyte powder (137.12 g dissolved in 2 000 mL warm water, stired until completely dissolved), patients of group B took polyethylene glycol electrolyte powder (same usage as group A) combined with prucalopride 2 mg/d for one day, patients of group C took polyethylene glycol electrolyte powder (same usage as group A) combined with prucalopride 2 mg/d for three days. The bowel preparation effects, especially ascending colon and ileocecal junction and cardiovascular adverse effects in all the patients and constipation patients of three groups were compared. Student t test, chi-square test and analysis of variance were performed for statistical analysis. Results A total of 124 elderly patients were divided into group A (64 cases), group B (23 cases) and group C (37 cases). Bowel preparation scores of total colon and ascending colon-ileocecal junction of group A, B, C were 8.34±0.90 and 2.56±0.56, 8.96±0.21 and 2.96±0.21, 8.86±0.35 and 2.86±0.35, respectively. The cleaning effects in total colon and ascending colon-ileocecal junction of group B were better than those of group A (t=5.52 and 5.15, both P 0.05). There were 33, 11 and 29 constipation cases in group A, B and C, respectively. The bowel preparation scores for total colon and ascending colon and ileocecal junction of group A, B, C were 7.85±0.94 and 2.24±0.56, 8.91±0.30 and 2.91±0.30, 8.83±0.38 and 2.83±0.38, respectively. The cleaning effects in total colon and ascending colon-ileocecal junction of group B were better than those of group A (t=6.72 and 5.49, both P 0.05). No obvious cardiovascular adverse events were observed in the patients of three groups. Conclusions The cleaning effects of prucalopride combined with polyethylene glycol electrolytes powder are good for colonoscopy examination in elderly patients, including elderly patients with constipation, especially in ascending colon and ilecocecal junction. No obvious cardiovascular adverse events are observed. Key words: Prucalopride; Polyethylene glycol electrolyte powder; Bowel preparation