Abstract
The objective of this study was to develop and evaluate of a floating presscoated pulsatile drug delivery system intended for treatment of early morning stiffness and symptomatic relief from pain in patients with rheumatoid arthritis with a distinct predetermined lag time of 8 h. Cores containing Aceclofenac as model drug were prepared by direct compression of different Sodium starch glycolate level CT-1 to CT-4) 8 %, 4%, 2% & without disinegrant and Aceclofenac as a model drug by using various proportion of polymers such Hydroxypropyl methylcellulose and Sodium bicarbonate floating layer is prepared. Fifteen formulations were prepared and formulation F15, F18, F22possessed good lag time 8 hr and showed pulsatile drug delivery pattern the tablets In- vitro evaluation tests. Results of this study indicated that by using floating-pulsatile release formulations are suitable to optimize pulsatile drug release formulation of Aceclofenac.
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