Abstract
A series of ferrocenyl‐containing benzothiazoles with amine side‐chains, both organosilane and carbon analogues, were prepared and fully characterised. The compounds were screened for their antiplasmodial activity against chloroquine‐sensitive (NF54) and chloroquine‐resistant (Dd2) strains of P. falciparum, displaying activities in the low micromolar range (0.1–1.9 µm). The moderate cytotoxicity of the benzothiazoles against a Chinese hamster ovarian (CHO) cell line demonstrated selective antiparasitic activity.
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