Abstract
Background: Obesity is a major public health issue which has been established to be a significant risk factor for several metabolic disorders such as impaired glucose tolerance, dyslipidaemia, and atherosclerosis. This study aimed to evaluate and compare the serum lipid profiles and glycated haemoglobin of obese and non-obese adults in Calabar, Nigeria. Methodology: This was a prospective comparative study that involved quantifying serum lipid profile and glycated hemoglobin (Hb) in seventy (70) obese subjects and thirty (30) non-obese control subjects. Results: The mean glycated Hb, Total Cholesterol (TC), Low Density Lipoprotein (LDL) and Tryglyceride (TG) for obese subjects were 6.13±2.76%, 4.92±1.23mmol/L, 3.18±1.21mmol/L, 1.21±0.40mmol/L, 128.14±12.65mmHg and 88.56±11.87mmHg respectively. These values were significantly higher than those of the non-obese control subjects whose mean values for glycated Hb, TC, LDL and TG were 5.34±1.15%, 3.08 ± 0.63mmol/L, 1.74 ± 0.54mmol/L, 0.67±0.33mmol/L (p 0.05). A positive correlation between BMI, glycated Hb, TC, LDL was observed in obese subjects (r=0.341, 0.287, 0.393, P<0.05), while a negative correlation was observed between BMI and HDL (r= -0.147, P<0.05), WHR and HDL (r= -0.289, P<0.05). Conclusion: Findings from this study show that obese individuals have higher risk to develop cardiovascular related disorders and type II diabetes mellitus if appropriate interventions are not considered.
Highlights
Obesity as defined by World Health Organization is a condition in which there is excessive fat accumulation in the body, to the extent that the health and wellbeing of the individual is adversely affected[1]
≥ 30kg/m2) of which consisted of 30 males and 40 females within the age range of 20-45 years were used as the test group and 30 apparently healthy nonobese subjects (BMI 18.5-24.9kg/m2) of which consisted of 10 males and 20 females were used as control group and were within the same age range as the test group
Anthropometric parameters, fasting serum lipid profile and glycated hemoglobin were determined in 70 obese subjects (BMI 30.0 kg/M2 and above) and 30 non obese control subject (BMI 18.5 – 24.9kg/m2)
Summary
Obesity as defined by World Health Organization is a condition in which there is excessive fat accumulation in the body, to the extent that the health and wellbeing of the individual is adversely affected[1]. This study aimed to evaluate and compare the serum lipid profiles and glycatedhaemoglobin of obese and non-obese adults in Calabar, Nigeria. Methodology:This was a prospective comparative study that involved quantifying serum lipid profile and glycated hemoglobin (HB1Ac) in seventy (70) obese subjects and thirty (30) non-obese control subjects. Results:The mean HB1Ac, Total Cholesterol (TC), Low Density Lipoprotein (LDL) and Tryglyceride (TG) for obese subjects were 6.13±2.76%, 4.92±1.23mmol/L, 3.18±1.21mmol/L, 1.21±0.40mmol/L, 128.14±12.65mmHg and 88.56±11.87mmHg respectively. These values were significantly higher than those of the non-obese control subjects whose mean values for HB1Ac, TC, LDL and TG were 5.34±1.15%, 3.08 ± 0.63mmol/L, 1.74 ± 0.54mmol/L, 0.67±0.33mmol/L (p
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