Evaluation of effectiveness of inosine glycyl-cysteinyl-glutamate disodium in acute severe poisoning with ethanol

Abstract

The results of the evaluation of the effectiveness of using inosine glycyl-cysteine-glutamate disodium (Molixan) in acute severe poisoning with ethanol are presented 57 cases of hospitalized patients (males) with I or II stage of alcoholic coma were investigated. Patients in the control group of 27 people received only the basic therapy of acute alcohol poisoning. 30 people from the main group in addition to basic therapy received moliksan drug at a dose of 3 mg/kg intravenously. Laboratory indicators of metabolic acidosis, which developed in patients of both groups, included by significant blood disorders of pH up to 7,24±0,02 and buffer capacity of blood to 6,2±0,15 mmol/l. The signs of hypoxia affiliated to metabolic acidosis: a decrease of partial pressure of oxygen (up to 64,3±5,18 mm Hg) and hemoglobin oxygen saturation (up to 74,4±5,6%), which were on average 1,6 times lower than normal values. The use of molixan promoted an earlier (3 hours instead of 10–12 h in the control) recovery of consciousness in patients poisoned with alcohol. Recovery of consciousness occurred on the background of a decrease in the severity of metabolic acidosis and hypoxia: blood pH in patients of the main group increased to 7,39±0,04; partial pressure of oxygen was 86,7±3,5 mm Hg. The oxygen saturation reached 96,2±3,3%. In general, moliksan is effective in rapid recovery of consciousness in patients in alcoholic coma. Additional inclusion of molixan in the treatment of acute severe intoxication with ethanol is accompanied by faster normalization of the parameters of the acid-base state and the blood gas composition compared to patients receiving only basic therapy.