Evaluation of effectiveness of concentrated growth factor on osseointegration

Cagasan Pirpir,Celal Candirli,Onur Yilmaz,Emre Balaban

doi:10.1186/s40729-017-0069-3

Cagasan Pirpir, Celal Candirli + Show 2 more

Open Access

https://doi.org/10.1186/s40729-017-0069-3

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Abstract

BackgroundGrowth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factors it contains. The aim of this study is to assess the effect of CGF on implant stability and osseointegration.MethodsTwelve patients with maxillary anterior toothless were included in the study. Implant cavities prepared in the study group were covered with CGF membrane before implant placement, but conventional implant placement was performed in the control group. Resonance frequency measurements were performed with the Osstell device intra-operatively, post-operatively, at the 1st week, and at the 4th week.ResultsThe mean ISQ values were found to be 79.40 ± 2.604 for the study group and 73.50 ± 5.226 for the control group at 1st week, 78.60 ± 3.136 for the study group and 73.45 ± 5.680 for the control group at 4th week. The differences between the groups were statistically significant (p < 0.05).ConclusionsIt was observed that the concentrated growth factor had positive effects on implant stabilization. The ISQ measurements at week 1 and week 4 were notably higher in the study group. Application of this material seems to accelerate osseointegration.

Highlights

Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration
A total of 40 implants were placed, 20 of these were included in the study group (50%), and the other 20 were included in the control group (50%)
It was determined that the differences between the groups were statistically significant (p < 0.05) and the ISQ measurements at week 1 and week 4 were notably higher in the study group (Fig. 4)

Summary

Introduction

Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. There is no standardization in terms of the time of osseointegration and the timing of prosthetic loading. Changes in implant surface properties and design have increased primer stability and helped the peri-implant tissue remain healthy. These changes have aimed to increase bone-implant surface connectivity and accelerate healing. Another method of accelerating osseointegration is the modulation of healing after the placement of the implant [2]. This modulation, in turn, can be achieved by bioactive molecules that increase osteoblastic differentiation and accelerate bone healing around the implant [2]

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