Evaluation of the effects of concentrated growth factors membrane on wound healing following gingivectomy and gingivoplasty operations: a randomized controlled clinical trial

Abstract

Aim This study aims to evaluate the effects of concentrated growth factors (CGF) membrane application on initial wound healing after gingivectomy and gingivoplasty surgeries. Methods and materials 20 patients with gingival enlargement who need gingivectomy or gingivoplasty surgery were selected to participate in this study. They were randomly divided into two groups of 10 patients each. Group-1 (Control group): where the gingivectomy sites were covered by a non-eugenol periodontal pack. Group-2 (Test group): were covered by the CGF membrane under the non-eugenol periodontal pack, postoperatively. Assessment of postoperative pain for both groups was recorded using the Visual Analog Scale for a period of 7 days. Laundry healing index, papillary bleeding index, and gingival index (GI) were also assessed at 7, 14, 21, and 28 days postoperatively. Results All patients experienced a decrease in postoperative pain throughout the study evaluation period, with no statistically significant differences between the two groups (P > 0.05), except for days 3 and 4, where there were statistically significant differences in favor of the test group (P < 0.05). On days 7 and 21, there was no difference in the healing index, but on days 14 and 28, there was a statistically significant difference (P < 0.05). The Papillary bleeding index (PBI) and gingival index of the two analyzed groups improved during the research period. At 21 days, the intergroup comparison showed a significant difference in PBI between the two studied groups (P > 0.05) in favor of the study group. Conclusion CGF membrane improved wound healing and reduced postoperative pain following gingivectomy or gingivoplasty surgery.